In response to your questions via email. I wanted to post a little about mitochondrial disease. I am backing up my computer so this is the short and sweet version. In Mitochondrial disease, symtoms generally occur when energy demand ( the body's energy requirement) exceeds energy supply ( the body's ability to supply energy). Symptoms can include leg pain, lethargy, severe headaches, abdominal pain, nausea and vomiting. All of these symptoms may be exacerabated by extreme physical activity, dehydration, or lack of eating. Physical activity is contraindicated in this child. Rather, by following certain precautions, these symptons can be avoided. Eating frequent meals will enhance the body's ability to make or use energy.